CS-2397
中文名称 | CS-2397 |
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中文同义词 | 甲亚油酰胺;化合物 T16036;(9Z,12Z)-N-(1-苯基乙基)十八碳-9,12-二烯酰胺 |
英文名称 | Melinamide |
英文同义词 | Melinamide;9,12-Octadecadienamide, N-(1-phenylethyl)-, (9Z,12Z)- (9CI);9,12-Octadecadienamide, N-(1-phenylethyl)-, (Z,Z)-;AC 223;DL-a-Methylbenzyl linoleamide;DL-N-(a-Methylbenzyl)linoleamide;Linoleamide, N-(a-methylbenzyl)- (8CI);N-(a-Methylbenzyl)linoleamide |
CAS号 | 14417-88-0 |
分子式 | C26H41NO |
分子量 | 383.61 |
EINECS号 | |
相关类别 | 抑制剂 |
Mol文件 | 14417-88-0.mol |
结构式 |
CS-2397 性质
熔点 | <4° |
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沸点 | bp0.03 200-215°; bp0.07 200-204° |
密度 | 0.928±0.06 g/cm3(Predicted) |
折射率 | nD23 1.5050; nD30 1.4863 |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 15.56±0.46(Predicted) |
形态 | 油状物 |
颜色 | 无色至浅黄 |
CAS 数据库 | 14417-88-0 |
IC50: 20.9 μM (cholesterol)
DL-Melinamide inhibits acyl CoA:cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA:cholesterol acyltransferase. D-Melinamide is found to be a more effective inhibitor than L-Melinamide.
Melinamide is a new hypocholesterolaemic drug. Melinamide causes a substantial decrease of the enhanced intestinal ACAT activity in diabetic rats, but does not affect intestinal cholesterol esterase activity. Furthermore, marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurrs concomitantly with the drug treatment.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-101722 | Melinamide | 1 mg | 909元 | |
2024/08/19 | HY-101722 | 甲亚油酰胺 Melinamide | 14417-88-0 | 5mg | 2000元 |