| Company Name: |
R&D Systems, Inc
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18003437475 18003437475 |
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| Products Intro: |
Product Name:Ac4ManNDAz
CAS:1015698-39-1
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| | D-Mannopyranose, 2-deoxy-2-[[3-(3-methyl-3H-diazirin-3-yl)-1-oxopropyl]amino]-, 1,3,4,6-tetraacetate Basic information |
| Product Name: | D-Mannopyranose, 2-deoxy-2-[[3-(3-methyl-3H-diazirin-3-yl)-1-oxopropyl]amino]-, 1,3,4,6-tetraacetate | | Synonyms: | D-Mannopyranose, 2-deoxy-2-[[3-(3-methyl-3H-diazirin-3-yl)-1-oxopropyl]amino]-, 1,3,4,6-tetraacetate;Ac4ManNDAz | | CAS: | 1015698-39-1 | | MF: | C19H27N3O10 | | MW: | 457.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1015698-39-1.mol | ![D-Mannopyranose, 2-deoxy-2-[[3-(3-methyl-3H-diazirin-3-yl)-1-oxopropyl]amino]-, 1,3,4,6-tetraacetate Structure](CAS/20210305/GIF/1015698-39-1.gif) |
| | D-Mannopyranose, 2-deoxy-2-[[3-(3-methyl-3H-diazirin-3-yl)-1-oxopropyl]amino]-, 1,3,4,6-tetraacetate Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | solubility | Ethanol:45.74(Max Conc. mg/mL);100.0(Max Conc. mM)
DMSO:45.74(Max Conc. mg/mL);100.0(Max Conc. mM) | | pka | 12.89±0.70(Predicted) |
| | D-Mannopyranose, 2-deoxy-2-[[3-(3-methyl-3H-diazirin-3-yl)-1-oxopropyl]amino]-, 1,3,4,6-tetraacetate Usage And Synthesis |
| Description | Ac4ManNDAz is a cell-permeable photo-crosslinking probe for studying glycoprotein or glycolipid interactions. The compound is an unnatural diazirine-containing monosaccharide building block, which acts as a photo-crosslinker. Once inside the cell, Ac4ManNDAz is metabolized and incorporated as photo-crosslinking sialic acid analogs into cell surface glycoproteins. Upon photoactivation with UV irradiation, the sialic acid appended diazirine is activated to a reactive carbene that covalently crosslinks to nearby molecules. | | Uses | Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins[1]. | | storage | Store at -20°C | | References | [1] Tanaka Y, et al. Photoactivatable crosslinking sugars for capturing glycoprotein interactions. J Am Chem Soc. 2008 Mar 19;130(11):3278-9. DOI:10.1021/ja7109772 |
| | D-Mannopyranose, 2-deoxy-2-[[3-(3-methyl-3H-diazirin-3-yl)-1-oxopropyl]amino]-, 1,3,4,6-tetraacetate Preparation Products And Raw materials |
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