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1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-

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1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
Synonyms:1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;SIAIS164018
CAS:2353492-68-7
MF:C43H48ClN10O7P
MW:883.33
EINECS:
Product Categories:
Mol File:2353492-68-7.mol
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Structure
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties
density 1.48±0.1 g/cm3(Predicted)
pka10.74±0.40(Predicted)
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Usage And Synthesis
DescriptionSIAIS164018 is a protein degrader. SIAIS164018 could degrade not only ALK fusion proteins in activating or G1202R-mutated form but also mutant EGFR with L858R + T790M, which are two most important targets in non-small-cell lung cancer. SIAIS164018 strongly inhibited cell migration and invasion of Calu-1 and MDA-MB-231. Surprisingly, SIAIS164018 degrades several important oncoproteins involved in metastasis such as FAK, PYK2, and PTK6. Interestingly, SIAIS164018 reshuffled the kinome ranking profile when compared to Brigatinib. SIAIS164018 is orally bioavailable and well tolerated in vivo. SIAIS164018 is an enlightening degrader for us to excavate the charm of protein degradation.
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-(2353492-68-7) Related Product Information