| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:TTBK1-IN-2
CAS:2765453-51-6
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
Zhengzhou convergence chemical co., LTD
|
| Tel: |
0371-0371-55153829 18003835034 |
| Email: |
2853979819@qq.com |
| Products Intro: |
Product Name:N-(4-(4-Chlorophenoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS:2765453-51-6
Purity:98% Package:100mg 250mg 500mg 1g 2g 5g 10g 25g 50g 100g 250g 500g 1kg
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| Company Name: |
Bide Pharmatech Ltd.
|
| Tel: |
400-1647117 15221909166 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:N-(4-(4-Chlorophenoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS:2765453-51-6
Purity:98% Package:1mg;5mg;10mg;25mg Remarks:BD01512693
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:TTBK1-IN-2
CAS:2765453-51-6
Purity:99.83% Package:1 mg;1 mL;10 mg;100 mg;25 mg;5 mg;50 mg
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| Company Name: |
RD International Technology Co., Limited
|
| Tel: |
18024082417 |
| Email: |
market@ubiochem.com |
| Products Intro: |
Product Name:TTBK1-IN-2
CAS:2765453-51-6
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
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| | TTBK1-IN-2 Basic information |
| Product Name: | TTBK1-IN-2 | | Synonyms: | TTBK1-IN-2;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[4-(4-chlorophenoxy)phenyl]-;N-(4-(4-Chlorophenoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | | CAS: | 2765453-51-6 | | MF: | C18H13ClN4O | | MW: | 336.77 | | EINECS: | | | Product Categories: | | | Mol File: | 2765453-51-6.mol |  |
| | TTBK1-IN-2 Chemical Properties |
| density | 1.421±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 50 mg/mL (148.46 mM; ultrasonic and adjust pH to 2 with HCl) | | pka | 12.81±0.50(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | TTBK1-IN-2 Usage And Synthesis |
| Biological Activity | TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 μM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice[1]. | | References | [1]. Nozal V, et al. TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. J Med Chem. 2022;65(2):1585-1607. |
| | TTBK1-IN-2 Preparation Products And Raw materials |
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