神经降压素
中文名称 | 神经降压素 |
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中文同义词 | 神经降压素?, >97% |
英文名称 | NEUROTENSIN |
英文同义词 | M.W. 1672.92 C78H121N21O20;GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU;NEUROTENSIN, BOVINE;NEUROTENSIN (HUMAN, BOVINE, CANINE);NEUROTENSIN (HUMAN, BOVINE, CANINE) 2ACOH 6H2O;NEUROTENSIN (1-13);NEUROTENSIN;PYR-LYENKPRRPYIL |
CAS号 | 39379-15-2 |
分子式 | C78H121N21O20 |
分子量 | 1672.92 |
EINECS号 | |
相关类别 | 多肽;目录多肽;Neuromedins and related;peptide |
Mol文件 | 39379-15-2.mol |
结构式 |
神经降压素 性质
RTECS号 | QQ4482000 |
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储存条件 | Desiccate at -20°C |
溶解度 | 不溶于乙醇; DMSO 中≥15.33 mg/mL;水中≥22.55 mg/mL |
形态 | 冻干粉。 |
颜色 | 白色至米白色 |
水溶解性 | Soluble to 0.70 mg/ml in water |
序列 | Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH |
Neurotensin receptors (NTR)
Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR, a member of the G-protein coupled receptor (GPCR) family, is present in a majority of human pancreatic and colorectal cancers, suggesting that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca 2+ ] i ), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-P0234 | 神经降压素 Neurotensin | 39379-15-2 | 1mg | 500元 |
2024/08/19 | HY-P0234 | 神经降压素 Neurotensin | 39379-15-2 | 5mg | 1500元 |