化合物TESMILIFENE FUMARATE
| 中文名称 | 化合物TESMILIFENE FUMARATE |
|---|---|
| 中文同义词 | 化合物TESMILIFENE FUMARATE;2-(4-苄基苯氧基)-N,N-二乙基乙胺 2-丁烯二酸(1:1);DPPE FUMARATE,抑制剂 |
| 英文名称 | DPPE FUMARATE |
| 英文同义词 | N,N-DIETHYL-2-[4-(PHENYLMETHYL)PHENOXY]ETHANAMINE FUMARATE;DPPE FUMARATE;Tesmilifene fumarate;inhibit,anti-histaminic,Tesmilifene fumarate,DPPE,Histamine Receptor,seizure,Tesmilifene,chemotherapy,Inhibitor;2-(4-Benzylphenoxy)-N,N-diethylethanamine 2-butenedioate(1:1) |
| CAS号 | 1185241-83-1 |
| 分子式 | C30H28O4P2 |
| 分子量 | 514.49 |
| EINECS号 | |
| 相关类别 | Histamine receptor |
| Mol文件 | Mol File |
| 结构式 |  |
化合物TESMILIFENE FUMARATE 性质
| 储存条件 | Desiccate at -20°C |
|---|---|
| 溶解度 | 在无菌水中可溶解至 100 mM |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
Tesmilifene fumarate (DPPE fumarate) 是 H1C 受体的拮抗剂，可广泛的增强化疗的细胞毒性，并保护正常细胞。
Tesmilifene may modulate the effects of 12(S)HETE in cancer cells, and indirectly, influence the susceptibility of cellular DNA to chemotherapy.
Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants.
| Animal Model: | Male BKTO mice (25-45 g). |
| Dosage: | 20 mg/kg (s.c.) and 20 μg (icv in 5 μL). |
| Administration: | S.C. and icv. |
| Result: | Potentiated seizures induced by both convulsants. |