| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PKM2 activator 3
CAS:1346113-84-5
Package:100mg/RMB 17500;25mg/RMB 10600;50mg/RMB 13800
|
| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Email: |
sigmaname@qq.com |
| Products Intro: |
Product Name:Pyruvate Kinase Activator
CAS:1346113-84-5
|
6-Quinolinesulfonamide, N-(3-chloro-4-fluorophenyl)-7-fluoro-1,2,3,4-tetrahydro-2-oxo- manufacturers
- PKM2 activator 3
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- $2500.00 / 100mg
-
2024-10-24
- CAS:1346113-84-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 6-Quinolinesulfonamide, N-(3-chloro-4-fluorophenyl)-7-fluoro-1,2,3,4-tetrahydro-2-oxo- Basic information |
| | 6-Quinolinesulfonamide, N-(3-chloro-4-fluorophenyl)-7-fluoro-1,2,3,4-tetrahydro-2-oxo- Chemical Properties |
| density | 1.564±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 100mg/mL, clear, colorless | | pka | 7.02±0.20(Predicted) | | form | powder | | color | white |
| | 6-Quinolinesulfonamide, N-(3-chloro-4-fluorophenyl)-7-fluoro-1,2,3,4-tetrahydro-2-oxo- Usage And Synthesis |
| Uses | PKM2 activator 3 is a potent PKM2 activator with an AC50 value of 90 nM. PKM2 activator 3 has good Caco-2 permeability, a low efflux ratio and high microsomal stability. PKM2 activator 3 can be used for researching anticancer[1].
(AC50:?the concentration which gives 50% activation of enzyme.) | | in vivo | PKM2 activator 3 (compound 66) has good Caco-2 permeability, a low efflux ratio (0.84) and high microsomal stability (t1/2 = 277.2 min in human liver microsomes and 117.5 min in mouse liver microsomes)[1]. | | References | [1] Walsh MJ, et al. 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6322-7. DOI:10.1016/j.bmcl.2011.08.114 |
| | 6-Quinolinesulfonamide, N-(3-chloro-4-fluorophenyl)-7-fluoro-1,2,3,4-tetrahydro-2-oxo- Preparation Products And Raw materials |
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