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1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]-

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1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Suppliers list
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:CAY10795
CAS:2241676-74-2
Purity:98% Package:1mg;5mg;10mg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:15-PGDH-IN-1
CAS:2241676-74-2
Purity:0 Package:5mg/RMB 5230;10mg/RMB 9880;1mg/RMB 1170
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Email: cayman@caymanchem.com
Products Intro: Product Name:CAY10795
CAS:2241676-74-2
1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Basic information
Product Name:1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]-
Synonyms:1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]-;CAY10795;SW222746;15-PGDH-IN-1
CAS:2241676-74-2
MF:C24H22N4O2
MW:398.46
EINECS:
Product Categories:
Mol File:2241676-74-2.mol
1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Structure
1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Chemical Properties
Boiling point 665.1±55.0 °C(Predicted)
density 1.293±0.06 g/cm3(Predicted)
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
form A crystalline solid
pka-0.94±0.30(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Usage And Synthesis
DescriptionCAY10795 is a 15-hydroxy prostaglandin dehydrogenase (15-PGDH) inhibitor (IC50 = 3 nM).1 It increases prostaglandin E2 (PGE2; ) levels greater than 3-fold in IL-1β-stimulated A549 human lung cells when used at a concentration of 500 nM. CAY10795 reduces 15-PGDH activity in the colon of mice when administered at a dose of 20 mg/kg and limits decreases in body weight and colon length and reduces colon ulceration in a mouse model of ulcerative colitis induced by dextran sodium sulfate (DSS; ) when administered at a dose of 40 mg/kg. It also accelerates recovery of circulating neutrophils following whole-body radiation and bone marrow transplant in mice when administered at a dose of 10 mg/kg twice per day.
References1. Hu, B., Toda, K., Wang, X., et al. Orally bioavailable quinoxaline inhibitors of 15-prostaglandin dehydrogenase (15-PGDH) promote tissue repair and regeneration J. Med. Chem. 65(22),15327-15343(2022).
1(2H)-Isoquinolinone, 2-methyl-6-[7-(1-piperidinylcarbonyl)-2-quinoxalinyl]- Preparation Products And Raw materials
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