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EMMX Biotechnology LLC
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888-539-0666 |
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info@emmx.com |
Products Intro: |
Product Name:VUF 8430 dihydrobromide CAS:100130-32-3 Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| 2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide Basic information |
Product Name: | 2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide | Synonyms: | 2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide;2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester;2-guanidinoethyl carbamimidothioate dihydrobromide;VUF 8430 dihydrobromide >=97% (NMR);VUF8430 hydrobromide;Carbamimidothioic acid, 2-[(aminoiminomethyl)amino]ethyl ester, dihydrobromide (9CI) | CAS: | 100130-32-3 | MF: | C4H13Br2N5S | MW: | 0 | EINECS: | | Product Categories: | | Mol File: | 100130-32-3.mol | |
| 2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide Chemical Properties |
storage temp. | room temp | solubility | deionized water: soluble24mg/mL | form | solid | color | White to off-white |
Hazard Codes | Xn | Risk Statements | 22-36/37/38 | Safety Statements | 26 | WGK Germany | 3 | RTECS | UM6960000 |
| 2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide Usage And Synthesis |
Description | VUF8430 is a histamine H4 receptor agonist (Ki = 31.6 nM). It is selective for histamine H4 over H1 and H3 receptors in radioligand binding assays (Kis = >1 and 1 μM, respectively) and is less active in isolated guinea pig atria, which endogenously expresses high levels of H2 receptors (pD2 = 3.8). VUF8430 inhibits forskolin-induced, cAMP-mediated increases in β-galactosidase activity (EC50 = 50.1 nM). In vivo, VUF8430 (30 mg/kg) enhances HCl-induced formation of gastric lesions in rats. It also reduces mechanical and thermal allodynia in a mouse model of peripheral neuropathy induced by spared nerve injury (SNI). | Uses | VUF 8430 Dihydrobromide is an H4 receptor agonist. | storage | Desiccate at RT |
| 2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide Preparation Products And Raw materials |
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