methyl 2-tetradecylglycidate
| 中文名称 | methyl 2-tetradecylglycidate |
|---|---|
| 中文同义词 | 帕莫酸甲酯;化合物 T11978 |
| 英文名称 | methyl 2-tetradecylglycidate |
| 英文同义词 | methyl 2-tetradecylglycidate;2-Tetradecyloxirane-2-carboxylic acid methyl ester;2-Tetradecyloxiranecarboxylic acid methyl ester;MCN-3716;Methyl palmoxirate;Methyl parmoxirate;McN3716 (Methyl palmoxirate;NSC359682) |
| CAS号 | 69207-52-9 |
| 分子式 | C18H34O3 |
| 分子量 | 298.46 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 69207-52-9.mol |
| 结构式 |  |
methyl 2-tetradecylglycidate 性质
| 熔点 | 44-46 °C |
|---|---|
| 沸点 | 361.4±17.0 °C(Predicted) |
| 密度 | 0.944±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
McN3716 是一种肉碱棕榈酰转移酶 I (CPT-1) 抑制剂。
Carnitine palmitoyltransferase I (CPT-1)
Inhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF 1α , a byproduct of PGI 2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-U00159 | methyl 2-tetradecylglycidate McN3716 | 69207-52-9 | 1 mg | 3950元 |