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N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine

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N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:DMH4
CAS:515880-75-8
Package:10 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:DMH 4
CAS:515880-75-8
Purity:NLT 98% Remarks:MC557873
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:DMH 4
CAS:515880-75-8
Package:100Mg,10Mg
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:DMH 4;6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyriMidine
CAS:515880-75-8
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
Company Name: ShangHai KenEn Chemical Technology Co., Ltd.  
Tel: 13120367189
Email: mychess007@163.com
Products Intro: Product Name:4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine
CAS:515880-75-8
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Basic information
Product Name:N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine
Synonyms:4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine;N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine;DMH-4;6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyriMidine;Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenyl-;DMH4,DMH-4
CAS:515880-75-8
MF:C24H24N4O2
MW:400.47
EINECS:
Product Categories:Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:515880-75-8.mol
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Structure
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Chemical Properties
density 1.25±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble20mg/mL
pka6.28±0.10(Predicted)
form powder
color off-white to brown
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Usage And Synthesis
DescriptionDMH4 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.16 μM in a cell-free assay) and a derivative of dorsomorphin . It selectively inhibits VEGFR2 over activin receptor-like kinase 2 (ALK2), ALK5, and AMPK (IC50s = 3.5, >30, and 8 μM, respectively, in a cell-free assay). DMH4 inhibits growth of H460 and A549 human lung cancer cells (GI50s = 13.3 and 2.8 μM, respectively) and reduces VEGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs; IC50 = 1 μM).
UsesDMH 4 is a selective VEGFR-2 inhibitor. DMH 4 displays antiangiogenic activity in vitro and in vivo.
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Preparation Products And Raw materials
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