Company Name: |
J & K SCIENTIFIC LTD.
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Tel: |
010-82848833 400-666-7788 |
Email: |
jkinfo@jkchemical.com |
Products Intro: |
Product Name:DMH 4 CAS:515880-75-8 Package:100Mg,10Mg
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Company Name: |
Chemsky (shanghai) International Co.,Ltd
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Tel: |
021-50135380 |
Email: |
shchemsky@sina.com |
Products Intro: |
Product Name:DMH 4;6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyriMidine CAS:515880-75-8 Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Basic information |
| N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Chemical Properties |
density | 1.25±0.1 g/cm3(Predicted) | storage temp. | 2-8°C | solubility | DMSO: soluble20mg/mL | pka | 6.28±0.10(Predicted) | form | powder | color | off-white to brown |
Hazard Codes | Xn | Risk Statements | 22 | WGK Germany | 3 |
| N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Usage And Synthesis |
Description | DMH4 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.16 μM in a cell-free assay) and a derivative of dorsomorphin . It selectively inhibits VEGFR2 over activin receptor-like kinase 2 (ALK2), ALK5, and AMPK (IC50s = 3.5, >30, and 8 μM, respectively, in a cell-free assay). DMH4 inhibits growth of H460 and A549 human lung cancer cells (GI50s = 13.3 and 2.8 μM, respectively) and reduces VEGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs; IC50 = 1 μM). | Uses | DMH 4 is a selective VEGFR-2 inhibitor. DMH 4 displays antiangiogenic activity in vitro and in vivo. |
| N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Preparation Products And Raw materials |
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