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anaplastic lymphoma kinase

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anaplastic lymphoma kinase Basic information
Product Name:anaplastic lymphoma kinase
Synonyms:anaplastic lymphoma kinase
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DescriptionAnaplastic lymphoma kinase (ALK) fusion in non-small cell lung cancer (NSCLC) was first described by Soda and colleagues in 2007. Using a retrovirus-mediated complementary DNA expression system, they discovered that a small inversion in the chromosome 2p results in a product consisting of portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the ALK gene. The fusion had transforming properties in mouse 3T3 fibroblast model and was targetable by ALK inhibitor WHI-P154 [1].
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