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| | 4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE Basic information |
| Product Name: | 4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE | | Synonyms: | 6,7-DIMETHOXY-N-(4-PHENOXYPHENYL)-4-QUINAZOLINAMINE;4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE;N-(6,7-DIMETHOXY-4-QUINAZOLINYL)-N-(4-PHENOXYPHENYL)AMINE;SRC KINASE INHIBITOR I | | CAS: | | | MF: | C22H19N3O3 | | MW: | 373.4 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE Chemical Properties |
| | 4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE Usage And Synthesis |
| Uses | Src Kinase inhibitor 1. The results showed that SKI-1 induced significant apoptosis in a dose-dependent manner in cancer cells with high basal Src activation. Src promotes survival and invasion of lung cancers with EGF receptor abnormalities and is a potential candidate for mol.-targeted therapy. | | Biological Activity | Potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC 50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC 50 values are 0.32 and 30 μ M respectively). Can be used in parallel with PP 1 and PP 2 to inhibit Src family kinases. |
| | 4-(4'-PHENOXYANILINO)-6,7-DIMETHOXYQUINAZOLINE Preparation Products And Raw materials |
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