4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene manufacturers
- SMPT
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- $0.00 / 100mg
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2024-03-21
- CAS:112241-19-7
- Min. Order: 100mg
- Purity: >95.00%
- Supply Ability: 100mg
- SMPT
-
- $0.00 / 50mg
-
2021-09-16
- CAS:112241-19-7
- Min. Order: 50mg
- Purity: 99%
- Supply Ability: 100KG
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| | 4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene Basic information |
| Product Name: | 4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene | | Synonyms: | 4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene;Benzoic acid, 4-[1-(2-pyridinyldithio)ethyl]-, 2,5-dioxo-1-pyrrolidinyl ester;2,5-dioxopyrrolidin-1-yl 4-(1-(pyridin-2-yldisulfaneyl)ethyl)benzoate;2,5-Dioxopyrrolidin-1-yl 4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoate;4-Succinimidyloxycarbonyl-α-Methyl-α-(2-Pyridyldithio)toluene | | CAS: | 112241-19-7 | | MF: | C18H16N2O4S2 | | MW: | 388.46 | | EINECS: | | | Product Categories: | | | Mol File: | 112241-19-7.mol |  |
| | 4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene Chemical Properties |
| storage temp. | 2-8°C | | solubility | Soluble in DMSO | | form | Solid | | color | Light yellow to yellow |
| | 4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene Usage And Synthesis |
| General Description | SMPT is a heterobifunctional sulfhydryl- and amine-reactive cross-linker. SMPT is used often for conjugating a toxin molecule to a monoclonal antibody directed against a cell-surface antigen. These immunotoxins produced with SMPT are highly potent as the cleavable disulfide imparts increased cytotoxicity compared to conjugates without a cleavable bond, such as those produced with SPDP. Also, next to the pyridine-2-thione in the spacer arm are a benzene ring and a methyl group adjacent to a carbon that hinders the disulfide bond, allowing exceptional conjugate stability in vivo. SMPT has the added benefit of being more stable to hydrolysis in aqueous solutions than other NHS cross-linkers. |
| | 4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene Preparation Products And Raw materials |
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