ONO4057
| 中文名称 | ONO4057 |
|---|---|
| 中文同义词 | 化合物 T16395 |
| 英文名称 | ONO-LB 457 |
| 英文同义词 | ONO-LB 457;ONO-4057;Benzenepropanoic acid, 2-(4-carboxybutoxy)-6-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-;ONO-4057,ONO4057 |
| CAS号 | 134578-96-4 |
| 分子式 | C27H34O7 |
| 分子量 | 470.55 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 134578-96-4.mol |
| 结构式 |  |
ONO4057 性质
| 沸点 | 704.8±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.173±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 4.68±0.10(Predicted) |
ONO4057 是 Leukotriene B4 受体的拮抗剂，其 IC50 值为 0.7±0.3 μM。
|
LTB 4 0.7 μM (IC 50 ) |
Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group.