| Company Name: |
Chengdu Youngshe Chemical Co., Ltd.
|
| Tel: |
+86-17380623303 +86-17380623303 |
| Email: |
Caroline@youngshechem.com |
| Products Intro: |
Product Name:ANQ 11125
CAS:153966-48-4
Purity:95% Package:1G; 10G; 100G
|
| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
|
| Tel: |
0571-87213919 |
| Email: |
Eric@peptidego.com |
| Products Intro: |
Product Name:ANQ 11125
CAS:153966-48-4
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
|
|
| | ANQ 11125 Basic information |
| Product Name: | ANQ 11125 | | Synonyms: | ANQ 11125;1-14-Motilin (swine), 3-L-phenylalanine-13-L-leucine- (9CI) | | CAS: | 153966-48-4 | | MF: | C86H125N19O21 | | MW: | 1761.03 | | EINECS: | | | Product Categories: | | | Mol File: | 153966-48-4.mol |  |
| | ANQ 11125 Chemical Properties |
| density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | pka | 3.25±0.10(Predicted) | | form | solid | | color | White |
| | ANQ 11125 Usage And Synthesis |
| Biological Activity | anq 11125 is a selective antagonist of motilin receptor with pkd of 8.24 [1].motilin receptor is a g protein-coupled receptor for motilin and stimulates contraction of gut smooth muscle.anq 11125 is a selective motilin receptor antagonist. the affinity of anq 11125 for motilin receptor is about 10 times less than motilin [1]. in rabbit antral smooth muscle tissue, anq-11125 bound to motilin receptor with pkd value of 8.16. while, anq-11125 didn’t induce contractions of rabbit duodenum. anq-11125 (10-5 m) induced contractile response by 29% compared to ach [2]. | | references | [1]. depoortere i, macielag mj, galdes a, et al. antagonistic properties of [phe3,leu13]porcine motilin. eur j pharmacol, 1995, 286(3): 241-247.
[2]. peeters tl, depoortere i, macielag mj, et al. the motilin antagonist anq-11125 blocks motilide-induced contractions in vitro in the rabbit. biochem biophys res commun, 1994, 198(2): 411-416. |
| | ANQ 11125 Preparation Products And Raw materials |
|