157263-00-8
中文名称 | 157263-00-8 |
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中文同义词 | |
英文名称 | MK 996 |
英文同义词 | MK 996;L-159282;Benzamide, N-[[4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl][1,1'-biphenyl]-2-yl]sulfonyl]- |
CAS号 | 157263-00-8 |
分子式 | C30H28N4O3S |
分子量 | 524.63 |
EINECS号 | |
相关类别 | |
Mol文件 | 157263-00-8.mol |
结构式 | ![]() |
157263-00-8 性质
密度 | 1.27±0.1 g/cm3(Predicted) |
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储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 4.70±0.10(Predicted) |
In the anesthetized chimpanzee, L-159282 (1 mg/kg, iv) produces 100% inhibition of the AII pressor response and is still active (52%) at 24 h. In aortic coarcted (high renin) rats, L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without reflex tachycardia. This dose of L-159282 reduces blood pressure to approximately the same level as both losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model.