cohort studies

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DescriptionIn contrast with case-control studies, cohort studies evaluate the frequency of illness in a group following an identified exposure compared to the frequency of illness in a group of unexposed controls. A Cohort study layout shown in Table 4. In contrast with a case-control study (which allows evaluation of multiple exposures possibly linked to a given disease), the cohort study allows evaluation of multiple disease outcomes for a single exposure.
Common measures of illness used in cohort studies of chronic disease are cancer incidence and cause-specific mortality. The majority of chronic disease studies employ mortality as the primary study outcome, but the incidence data are preferrable when available. For cancers with a low survival rate, such as lung cancer, the 2 outcomes may be roughly equivalent. For other cancers, such as prostate cancer or breast cancer, mortality may more strongly reflect access to medical care than disease incidence.
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