1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione
中文名称 | 1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione |
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中文同义词 | 1-(5-羟基己基)-3,7-二甲基嘌呤-2,6-二酮;化合物(R)-LISOFYLLINE;(R)-1-(5-羟基己基)-3,7-二甲基-1H-嘌呤-2,6(3H,7H)-二酮 |
英文名称 | 1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione |
英文同义词 | 1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione;3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione;CT 1501R;Lisophylline;ProTec;(R)-Lisofylline;3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-diMethyl-;1H-Purine-2,6-dione, 3,7-dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl- |
CAS号 | 100324-81-0 |
分子式 | C13H20N4O3 |
分子量 | 280.32 |
EINECS号 | |
相关类别 | Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals |
Mol文件 | 100324-81-0.mol |
结构式 |
1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione 性质
熔点 | 105-107°C |
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比旋光度 | D20 -5.6° (c = 6.7 in ethanol) |
沸点 | 511.2±56.0 °C(Predicted) |
密度 | 1.32±0.1 g/cm3(Predicted) |
储存条件 | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
溶解度 | 可溶于氯仿、甲醇 |
形态 | 固体 |
酸度系数(pKa) | 15.22±0.20(Predicted) |
颜色 | 白色至类白色 |
稳定性 | 吸湿性 |
IC50: 0.6 µM (Lysophosphatidic acid acyltransferase)
STAT4
(R)-Lisofylline blocks IL-12-driven Th1 differentiation and T cell proliferation in vitro, yet has no effect on IL-12 secretion from APCs ex vivo or in vitro.
(R)-Lisofylline reduces the impairment of insulin secretion induced by IL-1β in cultured rat islet cells, suppresses IFN-γ production, the onset of diabetes, and macrophage infiltration into islets from NOD mice, as well as Lisofylline improves insulin response and lowers glucose levels in Streptozotocin-treated rats after the oral glucose tolerance test.
(R)-Lisofylline prevents β cell dysfunction in NOD mice by inhibition of STAT4 phosphorylation which interrupts IL-12 signaling. (R)-Lisofylline ameliorates experimental allergic encephalomyelitis in mice.
(R)-Lisofylline also improves survival in mice injected with a lethal dose of LPS and ameliorates sepsis-induced lung injury in minipigs. In rats given IL-1 intratracheally (R)-Lisofylline pretreatment reduces lung leak but does not decrease neutrophil accumulation in lungs.
(R)-Lisofylline also suppresses release of TNF-α in vivo in mice and ex vivo in human blood stimulated with endotoxin derived from Salmonella or
Escherichia coli
.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-109854A | (R)-Lisofylline | 1 mg | 980元 | |
2024/04/30 | HY-109854A | 1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione (R)-Lisofylline | 100324-81-0 | 5mg | 1950元 |