(S)-(-)-卡维地洛
中文名称 | (S)-(-)-卡维地洛 |
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中文同义词 | 卡维地洛S-异构体;(S)-卡维地洛;S-卡维地络;化合物 T12794;卡维地洛杂质11(S异构体) |
英文名称 | (S)-(-)-CARVEDILOL |
英文同义词 | (-)-1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL;Carvedilol S-IsoMer;(S)-(-)-CARVEDILOL;2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-, (2S)-;2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-, (S)-;(2S)-1-(9H-Carbazole-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propane-2-ol;(S)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol;[S,(-)]-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol |
CAS号 | 95094-00-1 |
分子式 | C24H26N2O4 |
分子量 | 406.47 |
EINECS号 | |
相关类别 | API;Aromatics;Heterocycles;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 95094-00-1.mol |
结构式 |
(S)-(-)-卡维地洛 性质
熔点 | 114-115°C |
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沸点 | 655.2±55.0 °C(Predicted) |
密度 | 1.250±0.06 g/cm3(Predicted) |
储存条件 | -20°C Freezer |
溶解度 | 醋酸(微溶)、DMSO(微溶)、甲醇(微溶) |
形态 | 固体 |
酸度系数(pKa) | 13.90±0.20(Predicted) |
颜色 | 白色至类白色 |
稳定性 | 吸湿性 |
β/α-1 adrenergic receptor
The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers.
(S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro.
(S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs.
The optically active isomer of Carvedilol (C184625), a nonselective β-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-B0006B | (S)-(-)-卡维地洛 (S)-Carvedilol | 95094-00-1 | 5mg | 1100元 |
2024/04/30 | HY-B0006B | (S)-(-)-卡维地洛 (S)-Carvedilol | 95094-00-1 | 10mg | 1800元 |