Company Name: |
United States Biological
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Tel: |
1-800-520-3011 |
Email: |
sales@advtechind.com |
Products Intro: |
Product Name:Cephalotaxine|
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Company Name: |
United States Biological
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Tel: |
800.520.3011 or 781.639.5092 |
Email: |
chemicals@usbio.net |
Products Intro: |
Product Name:Cephalotaxine. CAS:24316-81-2
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Product Name: | CEPHALOTAXINE | Synonyms: | (-)-CEPHALOTAXINE;CEPHALOTAXINE;2-Nonadecanone, 1,1-dimethoxy-;Cephalotaxine Labeled d5 | CAS: | 24316-81-2 | MF: | C21H42O3 | MW: | 342.56 | EINECS: | | Product Categories: | | Mol File: | 24316-81-2.mol | ![CEPHALOTAXINE Structure](CAS/20200515/GIF/24316-81-2.gif) |
| CEPHALOTAXINE Chemical Properties |
Melting point | 131-134°C | storage temp. | Refrigerator | solubility | Chloroform, Methanol | form | Solid | color | White | CAS DataBase Reference | 24316-81-2 |
| CEPHALOTAXINE Usage And Synthesis |
Description | Cephalotaxine is a naturally occurring benzazepine alkaloid isolated from Cephalotaxus harringtonia.
Composition comprising cephalotaxine alkaloids is used as an antiangiogenic agent for the treatment of a host with an angiogenic disease or for prophylactic treatment of a host to inhibit the onset or progression of an angiogenic disease. Combined with an antiproliferative agent, cephalotaxine is also used for treatment of a host with cellular proliferative disease. Though cephalotaxine is inactive, its ester derivatives have shown antiviral, antitumor, and anticancer properties. Cephalatoxin esters (harringtonine, sioharringtonine, homoharringtonine) have shown significant activity against experimental P388 leukemia and against L-1210 leukemia in mice.
| References | [1] R. G. Powell, D. Weisleder, C. R. Smith, Jr. (1972) Antitumor alkaloids from Cephalotaxus harringtonia: Structure and activity, Journal of Pharmaceutical Sciences, 61, 1227-1230
[2] Patent WO 2004009030 A2: Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof
[3] Patent US 6734178 B2: Cephalotaxine alkaloid compositions and uses thereof
| Uses | Antiviral and antitumor agent. |
| CEPHALOTAXINE Preparation Products And Raw materials |
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