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(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one

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(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Basic information
Product Name:(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one
Synonyms:Pachystermine B;(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one;2-Azetidinone, 1-[(3β,4β,5α,20S)-20-(dimethylamino)-4-hydroxypregnan-3-yl]-3-(1-methylethyl)-, (3R)-
CAS:6157-00-2
MF:C29H50N2O2
MW:458.72
EINECS:
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Mol File:6157-00-2.mol
(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Structure
(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Chemical Properties
Melting point 256-8°C
Safety Information
MSDS Information
(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Usage And Synthesis
DescriptionThis alkaloid, in which the pregnane keto group of the preceding base is reduced to a secondary hydroxyl group, occurs in small amounts in Pachysandra termi_x0002_nalis Sieb. et Zucco It is laevorotatory having [O:]D - 18° (CHC13). Oxidation with chromic acid yields Pachystermine A.
ReferencesKikuchi, Uyeo., Tetrahedron Lett., 3473 (1965)
Kikuchi, Uyeo., Chern. Pharrn. Bull., 15, 549 (1967)
Partial synthesis:
Kikuchi et aZ., Tetrahedron Lett., 909 (1968)
(3R)-1-[(20S)-20-(Dimethylamino)-4β-hydroxy-5α-pregnan-3β-yl]-3-isopropylazetidin-2-one Preparation Products And Raw materials
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