- 6-Methoxynicotinamide
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- $0.00 / 1kg
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2025-04-03
- CAS:7150-23-4
- Min. Order: 1kg
- Purity: 99%min
- Supply Ability: 5000kg
- 6-Methoxynicotinamide
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- $0.00 / 20kg
-
2025-04-03
- CAS:7150-23-4
- Min. Order: 20kg
- Purity: 99%
- Supply Ability: 200000
- 6-Methoxynicotinamide
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- $0.00 / 25KG
-
2025-03-28
- CAS:7150-23-4
- Min. Order: 1KG
- Purity: 98.0%
- Supply Ability: 10000KGS
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| | 6-Methoxynicotinamide Basic information |
| Product Name: | 6-Methoxynicotinamide | | Synonyms: | 6-Methoxynicotinamide;3-PYRIDINECARBOXAMIDE, 6-METHOXY-;6-METHOXYPYRIDINE-3-CARBOXAMIDE;BUTTPARK 182\12-94;JBSNF-000088;JBSNF-000088
(JBSNF000088;6-methoxy-3-pyridinecarboxamide;Inhibitor,JBSNF 000088,inhibit,6-Methoxynicotinamide,JBSNF-000088 | | CAS: | 7150-23-4 | | MF: | C7H8N2O2 | | MW: | 152.15 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 7150-23-4.mol |  |
| | 6-Methoxynicotinamide Chemical Properties |
| Melting point | 178-180°C | | Boiling point | 301.6±22.0 °C(Predicted) | | density | 1.213±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 15.17±0.50(Predicted) | | color | Off-White to Pale Beige | | InChI | InChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10) | | InChIKey | KXDSMFBEVSJYRF-UHFFFAOYSA-N | | SMILES | C1=NC(OC)=CC=C1C(N)=O |
| | 6-Methoxynicotinamide Usage And Synthesis |
| Description | JBSNF-000088 is a cell penetrant, potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT) that reduces 1-methyl-nicotinamide (MNA) and improved glucose control in mice models of metabolic disease. JBSNF-000088 potently inhibits growth of PFA ependymoma cells. | | Biological Activity | JBSNF-000088 (6-Methoxynicotinamide) is a nicotinamide (NA) analog, a potent inhibitor of Nicotinamide N-methyltransferase (NNMT), against human NNMT (hNNMT), monkey NNMT (mkNNMT) and mouse NNMT (mNNMT) ) with IC50 values of 1.8 μM, 2.8 μM and 5.0 μM. | | in vitro | JBSNF-000088 (6-Methoxynicotinamide) has IC 50 values are 1.6 and 6.3 μM for U2OS or differentiated 3T3L1 cells. | | target |
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Target
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Value
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hNNMT
(Cell-free assay)
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1.8 μM
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mkNNM
(Cell-free assay)
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2.8 μM
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mNNMT
(Cell-free assay)
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5.0 μM
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| | 6-Methoxynicotinamide Preparation Products And Raw materials |
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