- A939572
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- $39.00 / 1mg
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2024-10-31
- CAS:1032229-33-6
- Min. Order:
- Purity: ≥95%
- Supply Ability: 10g
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| | 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Basic information |
| | 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Chemical Properties |
| Boiling point | 633.5±55.0 °C(Predicted) | | density | 1.302±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in H2O; ≥17.15 mg/mL in DMSO; ≥2.5 mg/mL in EtOH with ultrasonic | | form | solid | | pka | 13.65±0.70(Predicted) | | color | White to off-white |
| | 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Usage And Synthesis |
| Uses | 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide is a stearoyl-CoA desaturase 1 (SCD1) inhibitor. | | Biological Activity | A 939572 is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable. | | storage | Store at +4°C | | References | [1] xin z, zhao h, serby m d, et al. discovery of piperidine-aryl urea-based stearoyl-coa desaturase 1 inhibitors. bioorganic & medicinal chemistry letters, 2008, 18(15): 4298-4302.
[2] Low glycaemic diets alter lipid metabolism to influence tumour growth Authors: Lien Et al. Nature 2021;599:302. |
| | 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Preparation Products And Raw materials |
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