- Src Inhibitor 1
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- $33.00 / 1mg
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2024-11-19
- CAS:179248-59-0
- Min. Order:
- Purity: 99.38%
- Supply Ability: 10g
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| | 6,7-Dimethoxy-N-(4-phenoxyphenyl)- Basic information |
| | 6,7-Dimethoxy-N-(4-phenoxyphenyl)- Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | white powder | | color | White or off-white | | biological source | rabbit | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 |
| | 6,7-Dimethoxy-N-(4-phenoxyphenyl)- Usage And Synthesis |
| Description | Src-I1 (179248-59-0) is a potent and competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50‘s = 44 nM for Src and 88 nM for Lck). Src-I1 also inhibits VEGFR2 (IC50 = 320 nM). | | Uses | Src Kinase inhibitor 1
lung cancers with EGF receptor abnormalities and is a potential candidate for mol.-targeted therapy | | Uses | Src Inhibitor-1 may be used in Src kinase-mediated cell signaling studies. | | Definition | ChEBI: Src Inhibitor-1 is a member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a member of quinazolines, a secondary amino compound, an aromatic ether and a polyether. | | General Description | A potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src tyrosine kinase (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases only at higher concentrations (IC50 = 320 nM and 30 μM, respectively). | | Biochem/physiol Actions | Cell permeable: yes | | storage | Desiccate at RT | | References | 1) Tian et al. (2001) Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines; Biochem. 40 7084
2) Bain et al. (2007) The selectivity of protein kinase inhibitors: a further update; Biochem. J. 408 297 |
| | 6,7-Dimethoxy-N-(4-phenoxyphenyl)- Preparation Products And Raw materials |
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