CHPG SODIUM SALT
| 中文名称 | CHPG SODIUM SALT |
|---|---|
| 中文同义词 | 化合物 T10808;CHPG钠盐 |
| 英文名称 | (RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt |
| 英文同义词 | (RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt;CHPG Sodium salt |
| CAS号 | 1303993-73-8 |
| 分子式 | C8H7ClNNaO3 |
| 分子量 | 225.6 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1303993-73-8.mol |
| 结构式 |  |
CHPG SODIUM SALT 性质
| 储存条件 | Store at RT |
|---|---|
| 溶解度 | 在水中溶解度为 50 mM，在 DMSO 中溶解度为 50 mM |
| 形态 | 粉末 |
| 颜色 | 棕色 |
CHPG sodium salt 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG sodium salt 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。
|
mGlu 5
|
NF-κB
|
ERK
|
Akt
|
CHPG sodium salt (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO
2
derivatives treatment.
CHPG sodium salt (0.5 mM; 30 mins ) protects BV2 cells against SO
2
-induced apoptosis.
CHPG sodium salt (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
| Cell Line: | BV2 microglial cells |
| Concentration: | 10, 50, 100 and 500 µM |
| Incubation Time: | 24 hours |
| Result: | Increased the cell viability. |
Apoptosis Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 30 mins |
| Result: | Protected BV2 cells against SO 2 -induced apoptosis. |
Western Blot Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 30 mins |
| Result: | Increased the expression of TSG-6 in both mRNA and protein levels. |
CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
| Animal Model: | Adult Sprague-Dawley male rats weighing 280-320 g |
| Dosage: | 250 nM |
| Administration: | Injection; for 7 days |
| Result: | Reduced significantly cerebral lesion volume. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101364A | CHPG SODIUM SALT CHPG sodium salt | 1303993-73-8 | 5mg | 1100元 |
| 2024/04/30 | HY-101364A | CHPG SODIUM SALT CHPG sodium salt | 1303993-73-8 | 10 mg | 1800元 |