(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid
中文名称 | (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid |
---|---|
中文同义词 | 化合物 T15748;化合物LG100754 |
英文名称 | (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid |
英文同义词 | (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid;LG 100754;(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-2,4,6-Octatrienoic acid;2,4,6-Octatrienoic acid, 3-methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-, (2E,4E,6Z)-;UVI 2112;LG100754 >=98% (HPLC);CD 3159 |
CAS号 | 180713-37-5 |
分子式 | C26H36O3 |
分子量 | 396.56 |
EINECS号 | |
相关类别 | |
Mol文件 | 180713-37-5.mol |
结构式 | ![]() |
(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid 性质
沸点 | 549.4±50.0 °C(Predicted) |
---|---|
密度 | 1.003±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:可溶10mg/mL,澄清 |
酸度系数(pKa) | 4.74±0.33(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid 用途与合成方法
PPARα
|
PPARγ
|
LG100754 is a selective activator of endogenous RXR heterodimers.
LG100754 can also improve TNFα-mediated insulin resistance in mature adipocytes.
LG100754 acts as a bona fide activator of endogenous RXR:PPARγ heterodimers and regulator of insulin-dependent signaling pathways.
LG100754 (100 mg/kg) completely blocks the increase in glucose levels, suggesting that LG100754 can improve insulin resistance in vivo.
安全信息
WGK Germany | 3 |
---|
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-108523 | LG100754 | 1 mg | 2090元 | |
2024/04/30 | HY-108523 | (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid LG100754 | 180713-37-5 | 10mg | 7200元 |