4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
生物活性靶点体外研究体内研究 用途与合成方法 MSDS 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid价格(试剂级) 上下游产品信息
| 中文名称 | 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid |
|---|---|
| 中文同义词 | 化合物 T14689;4-[(1E)-2-[5,6-二氢-5,5-二甲基-8-(2-苯基乙炔基)-2-萘基]乙烯基]苯甲酸 |
| 英文名称 | 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid |
| 英文同义词 | 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid;BMS 493;(E)-4-[2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl]ethen-1-yl]benzoic acid;4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic acid;BMS204, 493;Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-;(E)-4-(2-(5,5-Dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl)vinyl)benzoic acid;BMS493,BMS-493 |
| CAS号 | 215030-90-3 |
| 分子式 | C29H24O2 |
| 分子量 | 404.5 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 215030-90-3.mol |
| 结构式 | ![4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid 结构式](CAS/20180808/GIF/215030-90-3.gif) |
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid 性质
| 沸点 | 605.4±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.21±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥20mg/mL |
| 酸度系数(pKa) | 4.27±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 浅黄色至厚黄色 |
BMS493 是一种反向泛视黄酸受体 (RARs) 激动剂。BMS493 增加了 RARs 与核共抑制因子的相互作用，还可阻止视黄酸诱导的分化。
|
RAR
|
BMS493 (100 nM; 6 days; ALDHhi UCB cells) treatment shows a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls. Newly expanded ALDHhi cells shows increased numbers of CD34 and CD133-positive cells, as well as a reduction in CD38 expression, a marker of hematopoietic cell differentiation.
Cell Viability Assay
| Cell Line: | ALDHhi UCB cells |
| Concentration: | 100 nM |
| Incubation Time: | 6 days |
| Result: | Showed a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls. |
Intrapancreatic transplantation of cell progeny after expansion of ALDHhi cells with or without BMS493 shows no reduction of hyperglycemia in Streptozotocin-treated NOD/SCID mice. Thus, Umbilical cord blood (UCB)-derived ALDHhi cells effectively lost islet regenerative capacity during ex vivo expansion.
安全信息
| WGK Germany | 2 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-108529 | BMS493 | 1 mg | 363元 | |
| 2024/04/30 | HY-108529 | 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid BMS493 | 215030-90-3 | 5mg | 800元 |