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6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:L-189
CAS:64232-83-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
CAS:64232-83-3
Purity:0.99 emma@coreychem.com Package:1000KG;100KG;1KG Emma
Company Name: Chemia Biotechnology（Shanghai） Co., Ltd
Tel: +8613816753574
Email: info@chemia-pharm.com
Products Intro: Product Name:L189
CAS:64232-83-3
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:L189
CAS:64232-83-3
Purity:98% Package:10mg Remarks:V23533
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:L189
CAS:64232-83-3
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Basic information
Product Name:6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
Synonyms:6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone;L189;4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-;(E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone;L 189;L189;6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
CAS:64232-83-3
MF:C11H10N4OS
MW:246.29
EINECS:
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Mol File:64232-83-3.mol
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Structure
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Chemical Properties
Melting point 250 °C (decomp)
density 1.45±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility ≥62.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka8.16±0.60(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Usage And Synthesis
DescriptionL189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 μM, respectively). It blocks DNA binding (Ki = 5 μM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.
UsesL189 has been shown to inhibit DNA ligases I, III, and IV and may have potential use in the development of anticancer agents.
storageStore at -20°C
references[1]. xi chen, shijun zhong, xiao zhu, et al. rational design of human dna ligase inhibitors that target cellular dna replication and repair. cancer res., 2008, 68(9): 3169-3177.
[2]. mark r. taylor, john a. conrad, daniel wahl, et al. kinetic mechanism of human dna ligase i reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency. journal of biological chemistry, 2011, 286(26): 23054-23062.
[3]. christian jekimovs, emma bolderson, amila suraweera, et al. chemotherapeutic compounds targeting the dna double-strand break repair pathways: the good, the bad, and the promising. frontiers in oncology, 2014, 4: article 86.
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Preparation Products And Raw materials
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