HZ-52 基本信息
| 中文名称 | HZ-52 |
|---|---|
| 中文同义词 | 2-((4-([1,1'-联苯]-4-基氨基)-6-氯嘧啶-2-基)硫代)辛酸;化合物 T21962 |
| 英文名称 | HZ-52 |
| 英文同义词 | HZ-52;2-[[4-([1,1'-biphenyl]-4-ylaMino)-6-chloro-2-pyriMidinyl]thio]octanoic Acid;Octanoic acid, 2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]-;MLNIGXYHGQLWLD-UHFFFAOYSA-N |
| CAS号 | 1077626-51-7 |
| 分子式 | C24H26ClN3O2S |
| 分子量 | 456 |
| EINECS号 | |
| 相关类别 | Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds |
| Mol文件 | 1077626-51-7.mol |
| 结构式 |  |
HZ-52 性质
| 沸点 | 625.3±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.29±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥10mg/mL |
| 酸度系数(pKa) | 3.03±0.21(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
用途
A potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7μM in intact human polymorphonuclear leukocytes. It also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally.
安全信息
| WGK Germany | 3 |
|---|