| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CAY10606
CAS:1159576-98-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylicacid,ethylester
CAS:1159576-98-3
Purity:NULL Package:1mg;2.5mg Remarks:NULL
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CAY10606
CAS:1159576-98-3
Purity:98% Package:1mg;5mg
|
|
| | CAY10606 Basic information |
| Product Name: | CAY10606 | | Synonyms: | CAY10606;2-[(3-Chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester;1H-Benz[g]indole-3-carboxylic acid, 2-[(3-chlorophenyl)methyl]-5-hydroxy-, ethyl ester | | CAS: | 1159576-98-3 | | MF: | C22H18ClNO3 | | MW: | 379.84 | | EINECS: | | | Product Categories: | | | Mol File: | 1159576-98-3.mol |  |
| | CAY10606 Chemical Properties |
| Melting point | 222 °C(Solv: ethyl acetate (141-78-6); cyclohexane (110-82-7)) | | Boiling point | 624.2±55.0 °C(Predicted) | | density | 1.355±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml | | form | A crystalline solid | | pka | 8.86±0.30(Predicted) |
| | CAY10606 Usage And Synthesis |
| Description | 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM).1 It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.1 | | References | 1. Karg, E.M., Luderer, S., Pergola, C., et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase J. Med. Chem. 52,3474-3483(2009). |
| | CAY10606 Preparation Products And Raw materials |
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