| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CAY10654
CAS:1298023-69-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CAY10654
CAS:1298023-69-4
Package:1mg/RMB 525;5mg/RMB 2250;10mg/RMB 3930
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CAY10654 Exclusive
CAS:1298023-69-4
Purity:98% Package:1mg;5mg;10mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:CAY10654
CAS:1298023-69-4
Package:>=98% Remarks:10857
|
CAY10654 manufacturers
- CAY10654
-
- $75.00 / 1mg
-
2024-11-19
- CAS:1298023-69-4
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | CAY10654 Basic information |
| Product Name: | CAY10654 | | Synonyms: | CAY10654;CAY10654 Exclusive;N'-(5-chloro-2-hydroxyphenyl)-N-octylpropanediamide;Propanediamide, N1-(5-chloro-2-hydroxyphenyl)-N3-octyl- | | CAS: | 1298023-69-4 | | MF: | C17H25ClN2O3 | | MW: | 340.85 | | EINECS: | | | Product Categories: | | | Mol File: | 1298023-69-4.mol |  |
| | CAY10654 Chemical Properties |
| Boiling point | 568.5±50.0 °C(Predicted) | | density | 1.186±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml | | form | A crystalline solid | | pka | 7?+-.0.70(Predicted) |
| | CAY10654 Usage And Synthesis |
| Description | The gram-negative pathogen Pseudomonas aeruginosa uses N-acylated-L-homoserine lactones (AHLs) in quorum sensing to modulate transcriptional activators, including LasR, and regulate the expression of virulence factors. The same AHLs suppress the host immune system. CAY10654 is a synthetic analog of natural AHLs that suppresses host immunity without inducing LasR.1 It inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 μM) without concurrent cytotoxicity.1 LasR is not induced by 100 μM CAY10654, although LasR is potently induced by natural AHL (5 μM) in positive control experiments.1 | | Definition | ChEBI: CAY10654 is an anilide. | | References | 1. Jadhav, G.P., Chhabra, S.R., Telford, G., et al. Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone J. Med. Chem. 54(9),3348-3359(2011). |
| | CAY10654 Preparation Products And Raw materials |
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