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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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Product Name:Eicosapentaenoyl Serotonin
CAS:199875-71-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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order@med-bio.cn |
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Product Name:Eicosapentaenoyl Serotonin
CAS:199875-71-3
Purity:98% Package:10mg (solution); 5mg (solution); 1mg (solution); 25mg (solution) Remarks:Medbio
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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marketing@energy-chemical.com |
| Products Intro: |
Product Name:EicosapentaenoylSerotonin
CAS:199875-71-3
Purity:NULL Package:1mg;2.5mg Remarks:NULL
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
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Product Name:Eicosapentaenoyl Serotonin Exclusive
CAS:199875-71-3
Purity:98% Package:1mg;5mg;10mg
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| Company Name: |
ApexBio Technology
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+ 1-832-696-8203 |
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sales@apexbt.com |
| Products Intro: |
Product Name:Eicosapentaenoyl Serotonin
CAS:199875-71-3
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| | Eicosapentaenoyl Serotonin Basic information |
| Product Name: | Eicosapentaenoyl Serotonin | | Synonyms: | Eicosapentaenoyl Serotonin;Eicosapentaenoyl Serotonin Exclusive;(5Z,8Z,11Z,14Z,17Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14,17-pentaenamide;5,8,11,14,17-Eicosapentaenamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-, (5Z,8Z,11Z,14Z,17Z)- | | CAS: | 199875-71-3 | | MF: | C30H40N2O2 | | MW: | 460.65 | | EINECS: | | | Product Categories: | | | Mol File: | 199875-71-3.mol |  |
| | Eicosapentaenoyl Serotonin Chemical Properties |
| Boiling point | 681.5±55.0 °C(Predicted) | | density | 1.053±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide | | form | solution in ethanol. | | pka | 10.08±0.40(Predicted) | | color | Colorless to light yellow |
| | Eicosapentaenoyl Serotonin Usage And Synthesis |
| Uses | Eicosapentaenoyl Serotonin is a dual fatty acid amide hydrolase and TRPV1 antagonist. | | Biological Activity | eicosapentaenoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. arachidonoyl serotonin is an inhibitor of fatty acid amide hydrolase (faah) and also acts as an antagonist of transient receptor potential vanilloid-type 1 (trpv1) channels. arachidonoyl serotonin is analgesic, reducing both acute and chronic peripheral pain in rodents [1, 2]. the effects of replacement the arachidonoyl portion with eicosapentaenoic acid have not been investigated. replacement of arachidonate with saturated 11- or 12-carbon fatty acids generated compounds that potently inhibited capsaicin-induced trpv1 channel activation with an ic50 of 0.76 μm. this compound showed no effects on blocking faah-mediated hydrolysis of arachidonoyl ethanolamide with an ic50 of > 50 μm [1]. | | references | [1] ortar, g. ,cascio, m.g.,de petrocellis, l., et al. new n-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. journal of medicinal chemistry 50, 6554-6569 (2007).
[2] maione, s. ,de petrocellis, l.,de novellis, v., et al. analgesic actions of n-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid trpv1 receptors. british journal of pharmacology 150, 766-781 (2007). |
| | Eicosapentaenoyl Serotonin Preparation Products And Raw materials |
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