| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:JGB1741
CAS:1256375-38-8
Purity:98% Package:5mg; 25mg; 10mg; 1mg Remarks:Medbio
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:JGB1741
CAS:1256375-38-8
Purity:97.24% Package:1 mg;10 mg;100 mg;25 mg;5 mg;50 mg
|
|
| | JGB1741 Basic information |
| Product Name: | JGB1741 | | Synonyms: | JGB1741;Benzo[b]thiophene-3-carboxamide, 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-;CRTIXRJWHKMWCH-STBIYBPSSA-N | | CAS: | 1256375-38-8 | | MF: | C27H24N2O2S | | MW: | 440.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1256375-38-8.mol |  |
| | JGB1741 Chemical Properties |
| Melting point | 242-243 °C | | Boiling point | 700.2±60.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤0.2mg/ml in DMSO;0.14mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 8.00±0.50(Predicted) | | color | Light yellow to yellow |
| | JGB1741 Usage And Synthesis |
| Description | The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to longevity, cancer, gene regulation, energy homeostasis, and apoptosis. JGB1741 is a small molecule inhibitor of SIRT1 with an IC50 value of 15 μM in a cell-free assay. It shows relatively weak inhibition for SIRT2 and SIRT3 with IC50 values greater than 100 μM. JGB1741 inhibits metastatic breast cancer MDA-MB 231 cell proliferation with an IC50 value of 512 nM in a cell-based assay and dose-dependently increases p53 acetylation and p53-mediated apoptosis in these cells. | | in vitro | jgb1741 potently inhibited the proliferation of human metastatic breast cancer cells, mda-mb 231. jgb1741 showed antitumor effects on three different cancer cell lines, k562, hepg2 and mda-mb 231 with an ic50 of 1, 10 and 0.5 μm, respectively. jgb1741-induced apoptosis has been associated with increase in cytochrome c release, modulation in bax/bcl2 ratio and cleavage of parp [1]. | | references | [1] kalle a m, mallika a, badiger j, et al. inhibition of sirt1 by a small molecule induces apoptosis in breast cancer cells[j]. biochemical and biophysical research communications, 2010, 401(1): 13-19.
[2] yamamoto h, schoonjans k, auwerx j. sirtuin functions in health and disease[j]. molecular endocrinology, 2007, 21(8): 1745-1755. |
| | JGB1741 Preparation Products And Raw materials |
|