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Product Name:ADX 10059 hydrochloride
CAS:757949-98-7
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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Product Name:ADX 10059 hydrochloride
CAS:757949-98-7
Purity:≥99% by HPLC Remarks:The hydrochloride salt form of ADX 10059, which has been reported to be a negative allosteric modulator.
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Product Name:ADX 10059 hydrochloride
CAS:757949-98-7
Purity:98% Package:50mg; 10mg Remarks:Medbio
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| | ADX 10059 hydrochloride Basic information |
| Product Name: | ADX 10059 hydrochloride | | Synonyms: | ADX 10059 hydrochloride;3-PyridinaMine, 2-[2-(3-fluorophenyl)ethynyl]-4,6-diMethyl-, hydrochloride;2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride | | CAS: | 757949-98-7 | | MF: | C15H14ClFN2 | | MW: | 276.74 | | EINECS: | | | Product Categories: | | | Mol File: | 757949-98-7.mol |  |
| | ADX 10059 hydrochloride Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | <6.92mg/ml in H2O; <27.67mg/ml in DMSO | | form | solid | | color | Yellow |
| | ADX 10059 hydrochloride Usage And Synthesis |
| Uses | ADX 10059 Hydrochloride is used in the synthetic preparation of novel 2-(hetero)arylalkynylpyridin-3-amines as mGluR5 antagonists. | | Biological Activity | adx 10059 hydrochloride is a potent and selective negative allosteric modulator of mglu5 receptor with ic50 value of 17.1 nm [1].metabotropic glutamate receptor 5 (mglu5 receptor) is a g protein-coupled receptor and is a receptor for glutamate, which is a primary neurotransmitter involved in signaling in the central nervous system [2].adx 10059 hydrochloride is a potent and selective mglu5 receptor negative allosteric modulator. in patients with migraine, adx10059 caused pain-free response in 16.1% patients compared with placebo of 4.5% [1]. in patients with gastro-oesophageal reflux disease (gord) underwent 24-h oesophageal ph-metry, adx10059 (250 mg) significantly reduced the percentage of acid exposure time with ph < 4 from 7.2% to 3.6%. also, adx 10059 significantly decreased the duration and number of symptomatic reflux episodes and reduced oesophageal acid exposure [2]. | | storage | Room temperature | | references | [1]. marin jc, goadsby pj. glutamatergic fine tuning with adx-10059: a novel therapeutic approach for migraine expert opin investig drugs, 2010, 19(4): 555-561.
[2]. keywood c, wakefield m, tack j. a proof-of-concept study evaluating the effect of adx10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. gut, 2009, 58(9): 1192-1199. |
| | ADX 10059 hydrochloride Preparation Products And Raw materials |
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