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Product Name:ADX 10059 hydrochloride CAS:757949-98-7 Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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BOC Sciences
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Product Name:ADX 10059 hydrochloride CAS:757949-98-7 Purity:≥99% by HPLC Remarks:The hydrochloride salt form of ADX 10059, which has been reported to be a negative allosteric modulator.
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MedBioPharmaceutical Technology Inc
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Product Name:ADX 10059 hydrochloride CAS:757949-98-7 Purity:98% Package:50mg; 10mg Remarks:Medbio
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| ADX 10059 hydrochloride Basic information |
Product Name: | ADX 10059 hydrochloride | Synonyms: | ADX 10059 hydrochloride;3-PyridinaMine, 2-[2-(3-fluorophenyl)ethynyl]-4,6-diMethyl-, hydrochloride;2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride | CAS: | 757949-98-7 | MF: | C15H14ClFN2 | MW: | 276.74 | EINECS: | | Product Categories: | | Mol File: | 757949-98-7.mol | ![ADX 10059 hydrochloride Structure](CAS/20211123/GIF/757949-98-7.gif) |
| ADX 10059 hydrochloride Chemical Properties |
storage temp. | Desiccate at RT | solubility | <6.92mg/ml in H2O; <27.67mg/ml in DMSO | form | solid | color | Yellow |
| ADX 10059 hydrochloride Usage And Synthesis |
Uses | ADX 10059 Hydrochloride is used in the synthetic preparation of novel 2-(hetero)arylalkynylpyridin-3-amines as mGluR5 antagonists. | Biological Activity | adx 10059 hydrochloride is a potent and selective negative allosteric modulator of mglu5 receptor with ic50 value of 17.1 nm [1].metabotropic glutamate receptor 5 (mglu5 receptor) is a g protein-coupled receptor and is a receptor for glutamate, which is a primary neurotransmitter involved in signaling in the central nervous system [2].adx 10059 hydrochloride is a potent and selective mglu5 receptor negative allosteric modulator. in patients with migraine, adx10059 caused pain-free response in 16.1% patients compared with placebo of 4.5% [1]. in patients with gastro-oesophageal reflux disease (gord) underwent 24-h oesophageal ph-metry, adx10059 (250 mg) significantly reduced the percentage of acid exposure time with ph < 4 from 7.2% to 3.6%. also, adx 10059 significantly decreased the duration and number of symptomatic reflux episodes and reduced oesophageal acid exposure [2]. | storage | Room temperature | references | [1]. marin jc, goadsby pj. glutamatergic fine tuning with adx-10059: a novel therapeutic approach for migraine expert opin investig drugs, 2010, 19(4): 555-561. [2]. keywood c, wakefield m, tack j. a proof-of-concept study evaluating the effect of adx10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. gut, 2009, 58(9): 1192-1199. |
| ADX 10059 hydrochloride Preparation Products And Raw materials |
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