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N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide

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N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:MARK-IN-1
CAS:1109283-93-3
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:N-((1R,6R)-6-amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide
CAS:1109283-93-3
Purity:95% Remarks:MC778824
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:MARK-IN-1
CAS:1109283-93-3
Purity:0 Package:50mg/RMB 18300;25mg/RMB 13900;100mg/RMB 23500
Company Name: Matrix Scientific  
Tel: 803 788-9494 All other calls
Email: sales@matrixscientific.com
Products Intro: CAS:1109283-93-3
Purity:95+% Package:$706.00/250mg;$1,568.00/1g
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Basic information
Product Name:N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide
Synonyms:N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide;N-((1R,6R)-6-Amino-2,2-difluorocyclohexyl)-5-methyl-4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a;N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide;2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-;MARK-IN-1;MARK IN 1,MARKIN1
CAS:1109283-93-3
MF:C22H23F2N7OS
MW:471.53
EINECS:
Product Categories:
Mol File:1109283-93-3.mol
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Structure
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Usage And Synthesis
Description

MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM.

MARK-IN-1 (Compound 25) is a potent MARK inhibitor. Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1].

References

[1]. Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4362-6.

N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide Preparation Products And Raw materials
Tag:N-((1R,6R)-6-aMino-2,2-difluorocyclohexyl)-5-Methyl-4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyriMidin-3-yl)thiophene-2-carboxaMide(1109283-93-3) Related Product Information