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| | BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- Basic information |
| | BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- Chemical Properties |
| Boiling point | 386.6±22.0 °C(Predicted) | | density | 1.363±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble20mg/mL, clear | | pka | 11.76±0.43(Predicted) | | form | powder | | color | white to beige |
| WGK Germany | 3 | | HS Code | 2933.99.8290 |
| | BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- Usage And Synthesis |
| Uses | OAC1 enhances iPSC reprogramming efficiency. | | General Description | A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1 μM OAC1 treatment starts 48 h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294 (Cat. No. 382190), Tranylcypromine (Cat. No. 616431), VPA (Cat. No. 676380), and Vitamin C (Cat. No. 1813), in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO (Cat. No. 361550) is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. | | Biochem/physiol Actions | Cell permeable: yes | | storage | +4°C |
| | BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- Preparation Products And Raw materials |
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