OMACICLOVIR
| 中文名称 | OMACICLOVIR |
|---|---|
| 中文同义词 | 化合物 T28234 |
| 英文名称 | OMaciclovir |
| 英文同义词 | H2G;H 2G;ABT-091;ABT091;ABT 091;(-)-2HM-HBG;6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]- |
| CAS号 | 124265-89-0 |
| 分子式 | C10H15N5O3 |
| 分子量 | 253.26 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 124265-89-0.mol |
| 结构式 |  |
OMACICLOVIR 性质
| 密度 | 1.68±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：230 mg/mL（908.16 mM） |
| 酸度系数(pKa) | 9.61±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Omaciclovir (H2G) 是一种有效的选择性疱疹病毒 herpesvirus 复制抑制剂。Omaciclovir 是一种核苷类似物。
Omaciclovir is a nucleoside analog with in vitro inhibitory activity against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and -2), Epstein-Barr virus, and human herpesvirus 6. Omaciclovir is also efficacious in simian varicella virus-infected monkeys.
Omaciclovir shows antiviral activities against different human herpesviruses with EC
50
s of 0.72 ± 0.1, 0.62 ± 0.2, 0.015 ± 0.004, 0.048 ± 0.023, 0.047 ± 0.004, 0.035 ± 0.022, and 0.016 ± 0.003 μM for MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively.