| Company Name: |
MedChemexpress LLC
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021-58955995 |
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sales@medchemexpress.cn |
| Products Intro: |
Product Name:ABT 894
CAS:799279-80-4
Purity:>98% Package:3600RMB/1mg
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| | ABT 894 Basic information |
| Product Name: | ABT 894 | | Synonyms: | ABT 894;A 422894.0;Sofiniclin;Sofinicline;ABT-894; ABT 894; ABT894;3,6-Diazabicyclo[3.2.0]heptane, 3-(5,6-dichloro-3-pyridinyl)-, (1S,5S)- | | CAS: | 799279-80-4 | | MF: | C10H11Cl2N3 | | MW: | 244.12 | | EINECS: | | | Product Categories: | | | Mol File: | 799279-80-4.mol |  |
| | ABT 894 Chemical Properties |
| Boiling point | 417.4±45.0 °C(Predicted) | | density | 1.406±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 10.31±0.20(Predicted) | | color | Off-white to brown |
| | ABT 894 Usage And Synthesis |
| Biological Activity | Sofiniclin (ABT 894) is an agonist of nAChR as a potential non-stimulatory study in attention deficit disorder. | | in vitro | ABT 894 is more potent than ABT-089 at both receptor subtypes, with K i values of 1.9 nM for 125 I-α-conotoxinMII binding and of 1.3 nM for 125 I-epibatidine binding. | | in vivo | ABT 894 (0.001 to 0.10 mg/kg, po) produces significant reductions in LIDs compared to vehicle monkey. It does not decrease LIDs in monkeys with severe nigrostriatal damage. < p> |
| | ABT 894 Preparation Products And Raw materials |
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