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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037 |
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3bsc@sina.com |
| Products Intro: |
Product Name:Bax inhibitor peptide P5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
AdooQ BioScience, LLC
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+1 (866) 930-6790 |
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info@adooq.com |
| Products Intro: |
Product Name:Bax inhibitor peptide P5
CAS:579492-83-4
Purity:98% Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
Absin Bioscience Inc.
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| Tel: |
021-38015121 15000105423 |
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chenjw@absin.cn |
| Products Intro: |
Product Name:Bax inhibitor peptide P5
CAS:579492-83-4
Purity:>98% Package:100mg;5mg;10mg
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| Company Name: |
MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:BAX INHIBITOR PEPTIDE P5
CAS:579492-83-4
Purity:98% Package:10mg; 100mg; 5mg Remarks:Medbio
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| Company Name: |
ApexBio Technology
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+ 1-832-696-8203 |
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sales@apexbt.com |
| Products Intro: |
Product Name:Bax inhibitor peptide P5
CAS:579492-83-4
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| | BAX INHIBITOR PEPTIDE P5 Basic information |
| | BAX INHIBITOR PEPTIDE P5 Chemical Properties |
| Boiling point | 1001.4±65.0 °C(Predicted) | | density | 1.238±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | solubility | ≥61.7 mg/mL in DMSO; ≥101 mg/mL in EtOH with ultrasonic; ≥94.4 mg/mL in H2O | | form | solid | | pka | 3.16±0.10(Predicted) |
| | BAX INHIBITOR PEPTIDE P5 Usage And Synthesis |
| Uses | Bax Inhibitor Peptide P5 is a cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain. Acts as an effective Inhibitor for Bax-mediated apoptosis (~50-200 uM). | | Biological Activity | bax inhibitor peptide p5 (bip p5) is a peptide inhibitor of bax translocation to mitochondria [1].bax is a pro-apoptotic member of bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. bax stays in the cytosol and transfers into mitochondria after apoptotic stimuli [1].bip p5 is a membrane-permeable peptide inhibitor of bax translocation to mitochondria. in hela cells, bip p5 protected cells from uvc- and sts-induced apoptosis. in u87-mg glioma cells, mcf-7 breast cancer cells and lncap prostate cancer cells, bip p5 also inhibited apoptosis induced by anti-cancer drugs cisplatin, etoposide and doxorubicin. while bip p5 did not suppress uvc- or sts-induced apoptosis in bax-deficient cells (du145), which suggested bip p5 only suppressed bax-mediated apoptosis. the caspase activation and the release of cytochrome c from mitochondria triggered by apoptotic stimuli were also significantly inhibited by bip p5. bip p5 inhibited the interaction of ku70 and endogenous bax in a dose-dependent way [1]. | | references | [1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357. |
| | BAX INHIBITOR PEPTIDE P5 Preparation Products And Raw materials |
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