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N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:N-Desmethyltamoxifen
CAS:31750-48-8
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
CAS:31750-48-8
Purity:98% Package:1KG;3.07USD
Company Name: Nextpeptide Inc
Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Products Intro: Product Name:2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N-methylethanamine HCl
CAS:31750-48-8
Purity:98% Min. Package:5KG;1KG
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139
Email: orders@jknbiochem.com
Products Intro: Product Name:N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
CAS:31750-48-8
Purity:0.98 Package:10G:100G
Company Name: QUALITY CONTROL SOLUTIONS LTD.
Tel: 0755-66853366; 13670046396
Email: ORDERS@QCSRM.COM
Products Intro: Product Name:Tamoxifen Citrate EP Impurity F
CAS:31750-48-8
Purity:0.95 Package:10mg; 25mg;50mg;100mg Remarks:Brand: QCS; Can provide COA, hydrogen spectrum, mass spectrometry, liquid phase; Level: Pharmaceutical Impurity Standard
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Basic information
Product Name:N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE
Synonyms:(Z)-2-[4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY]-N-METHYL-ETHANAMINE;N-DESMETHYL TAMOXIFEN HCL;N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE;N-DEMETHYLTAMOXIFEN, HYDROCHLORIDE;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(4-((z)-ethanamin;2-diphenyl-1-butenyl)phenoxy)-n-methyl-2-(p-((z)-ethylamin;cis-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-n-methylethylamine;desmethyltamoxifen
CAS:31750-48-8
MF:C25H27NO
MW:357.49
EINECS:
Product Categories:
Mol File:31750-48-8.mol
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Structure
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Chemical Properties
Boiling point 485.8±33.0 °C(Predicted)
density 1.047±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 72 mg/mL (201.40 mM);Ethanol: 36 mg/mL (100.70 mM)
pka9.38±0.10(Predicted)
Water Solubility Water: Insoluble
Safety Information
MSDS Information
N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Usage And Synthesis
DefinitionChEBI: N-Desmethyltamoxifen is a stilbenoid.
Biological ActivityN-Desmethyltamoxifen is the main metabolite of Tamoxifen in the human body. N-Desmethyltamoxifen, a weaker antiestrogen, is a protein kinase C (PKC) inhibitor ten times stronger than Tamoxifen. It is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis and sphingosine phosphorylation.
in vitro

N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
It inhibits growth of MCF 7 human mammary carcinoma cells.
N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen.

Cell Viability Assay

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Cell Line: MCF 7 human mammary carcinoma cells
Concentration: 1.5, 2.5, 5, 7.5, 10 μM
Incubation Time: 114 hours
Result: Inhibits growth of MCF 7 human mammary carcinoma cells
target< /table>

PKC

Estrogen Receptor

N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE Preparation Products And Raw materials
Tag:N-DESMETHYLTAMOXIFEN, HYDROCHLORIDE(31750-48-8) Related Product Information
Tamoxifen