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J & K SCIENTIFIC LTD.
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Products Intro: |
Product Name:5'-O-Tritylinosine CAS:4152-77-6 Package:100Mg,1g
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| 5’O-Tritylinosine Basic information |
Product Name: | 5’O-Tritylinosine | Synonyms: | 5’O-Tritylinosine;KIN-59;Inosine, 5'-O-(triphenylmethyl)-;5'-O-tritylinosine-2'-deoxyinosine;5'-O-Trt-rI;5'-O-Trt-rI | CAS: | 4152-77-6 | MF: | C29H26N4O5 | MW: | 510.54 | EINECS: | | Product Categories: | | Mol File: | 4152-77-6.mol | ![5’O-Tritylinosine Structure](CAS/GIF/4152-77-6.gif) |
| 5’O-Tritylinosine Chemical Properties |
solubility | DMF: 5 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 0.3 mg/mL | form | A crystalline solid | color | White to off-white |
| 5’O-Tritylinosine Usage And Synthesis |
Description | KIN59 is a purine riboside derivative that allosterically inhibits thymidine phosphorylase (TPase; IC50s = 44 and 67 μM for purified E. coli and human enzymes, respectively). Through this action, KIN59 blocks the conversion of thymidine to thymine. KIN59 inhibits TPase-induced angiogenesis in a chicken chorioallantoic membrane assay and reduces endothelial cell migration without impacting proliferation. KIN59 also inhibits the binding of fibroblast growth factor 2 (FGF2) to FGF receptor 1, preventing the growth and neovascularization of subcutaneous tumors induced by FGF2-transformed endothelial cells injected in immunodeficient nude mice. | Uses | 5’O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase. | Uses | 5’-O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase. |
| 5’O-Tritylinosine Preparation Products And Raw materials |
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