| Company Name: |
DKMbiochem.Co. Ltd
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| Tel: |
15901859516 |
| Email: |
sales@DKMbiochem.com |
| Products Intro: |
Product Name:3-?[3-?(4-?Methoxyphenyl)-?1-?oxo-?2-?propen-?1-?yl]-?4-?phenyl-?2(1H)-?quinolinone
CAS:1402830-75-4
Purity:98% Package:1g,5g Remarks:Ceranib-2
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Ceranib-2
CAS:1402830-75-4
Purity:98% Package:1G;10G;100G Remarks:Ceranib-2 is an inhibitor of cellular ceramidase activity, which can inhibit ceramidase activity with IC50 of 28 μM in SKOV3 cells. It can catalyze the hydrolysis of the N-acyl linkage between the fat
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| | 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Basic information |
| | 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | color | white to beige |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Usage And Synthesis |
| Description | Ceranib-2 is a ceramidase inhibitor that inhibits ceramidase activity (IC50 = 28 μM in SKOV3 cells). It also increases intracellular accumulation of various ceramides, including C14 ceramide , C24 ceramide , C26 ceramide, and C26:1 ceramide, and total ceramide levels and decreases levels of dihydrosphingosine, sphingosine, and sphingosine-1-phosphate in SKOV3 cells. In vivo, ceranib-2 (20 and 50 mg/kg, i.p.) reduces tumor volume in a JC mammary adenocarcinoma mouse syngeneic tumor model. |
| | 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Preparation Products And Raw materials |
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