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Product Name: | FLLL31 | Synonyms: | FLLL31;Tetramethylcurcumin;(E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;FLLL31;FLLL-31;FLLL 31;1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-, (1E,6E)-;FLLL31 >=98% (HPLC);(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione | CAS: | 52328-97-9 | MF: | C25H28O6 | MW: | 424.49 | EINECS: | | Product Categories: | | Mol File: | 52328-97-9.mol | ![FLLL31 Structure](CAS/20180808/GIF/52328-97-9.gif) |
| FLLL31 Chemical Properties |
Boiling point | 594.5±50.0 °C(Predicted) | density | 1.140±0.06 g/cm3(Predicted) | storage temp. | 2-8°C | solubility | DMSO: ≥10mg/mL | form | powder | color | yellow |
| FLLL31 Usage And Synthesis |
Biological Activity | Tetramethylcurcumin (FLLL31) is derived from curcumin and specifically inhibits phosphorylation of STAT3 by selectively binding to Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anticancer effects. | in vitro | Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulas STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. Tetramethylcurcumin inhibits cell viability , cell invasion. Tetramethylcurcumin is an effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines. | target | |
| FLLL31 Preparation Products And Raw materials |
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