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| | 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Basic information |
| Product Name: | 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER | | Synonyms: | BML-111;5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER;6(R)-7-trihydroxymethyl Heptanoate;Heptanoic acid, 5,6,7-trihydroxy-, methyl ester, (5S,6R)-;(5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE;1,3-Benzodioxole-9-sulfonylchloride;5(S),6(R)-trihydroxy-7-heptanoic acid, methyl ester;BML111,BML 111 | | CAS: | 78606-80-1 | | MF: | C8H16O5 | | MW: | 192.21 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Chemical Properties |
| Boiling point | 360.8±42.0 °C(Predicted) | | density | 1?+-.0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | H2O: ≥20mg/mL | | pka | 13.74±0.20(Predicted) | | form | powder | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| | 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Usage And Synthesis |
| Description | BML-111 (78606-80-1) novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat model.2 Displays hepatoprotective effects in acetaminophen-induced liver injury in mice.3 Limits inflammatory damage in the cerebral cortex and helps maintain blood brain barrier integrity in a rat model of ischemic stroke.4 Attenuates renal ischemia/reperfusion injury via activation of p38 MAPK/PPARa/HO-1 pathway.5 | | Uses | 5(S),6(R)-7-trihydroxymethyl Heptanoate is a potent lipoxin A4 agonist. | | storage | Store at -20°C | | References | 1) Lee et al. (1991), Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: structure-function relationships; Biochem. Biophys. Res. Commun., 180 1416
2) Li et al. (2013), BML-111 attenuates hemorrhagic shock-induced acute lung injury through inhibiting activation of mitogen-activated protein kinase pathway in rats; J. Surg. Res., 183 710
3) El-Agamy et al. (2014), Protective effects of BML-111 against acetaminophen-induced acute liver injury in mice; J. Physiol. Biochem., 70 141
4) Hawkins et al. (2014), Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke; J. Neurochem., 129 130
5) Wu et al. (2016), BML-111-Attenuates renal Ischemia/Reperfusion Injury via Peroxisome Proliferator-Activates Receptor-α-Regulated Heme Oxygenase-1; Inflammation, 39 611 |
| | 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Preparation Products And Raw materials |
| Raw materials | 2-Heptenoic acid, 5,6,7-trihydroxy-, methyl ester, (2E,5S,6R)--->2-Heptenoic acid, 5,6,7-trihydroxy-, methyl ester, (5S,6R)- |
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