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| Product Name: | BGG463 | | Synonyms: | BGG463;K 03859;BGG463 (K03859);BGG 463;BGG-463;CS-2570;K 0859;6-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]naphthalene-1-carboxamide;BGG463,K03859,inhibit,CDK,Cyclin dependent kinase,Inhibitor,K 03859,BGG-463,BGG 463,K-03859 | | CAS: | 890129-26-7 | | MF: | C30H29F3N6O3 | | MW: | 578.58 | | EINECS: | | | Product Categories: | | | Mol File: | 890129-26-7.mol |  |
| | BGG463 Chemical Properties |
| Boiling point | 669.0±55.0 °C(Predicted) | | density | 1.366±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 125 mg/mL (216.05 mM) | | pka | 12.06±0.70(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | BGG463 Usage And Synthesis |
| Biological Activity | BGG463 (K03859) is an orally active inhibitor of type II CDK2. | | in vitro | BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML. | | target | |
| | BGG463 Preparation Products And Raw materials |
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