化合物RO2959 HYDROCHLORIDE
| 中文名称 | 化合物RO2959 HYDROCHLORIDE |
|---|---|
| 中文同义词 | 化合物RO2959 HYDROCHLORIDE |
| 英文名称 | RO2959 Hydrochloride |
| 英文同义词 | RO2959 Hydrochloride;RO2959 HCl;IP3,SOCE,Ca2+ release-activated Ca2+ channels,RO2959 Hydrochloride,Interleukin Related,inhibit,IL-2,Stim1,RO-2959 Hydrochloride,CRAC Channel,anti-proliferation,RO 2959,Calcium release-activated channels,T-cell,RO-2959,Orai1,heart,RO2959,Inhibitor,failure;SYN5226 |
| CAS号 | 1219927-22-6 |
| 分子式 | C21H20ClF2N5OS |
| 分子量 | 463.93 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1219927-22-6.mol |
| 结构式 |  |
化合物RO2959 HYDROCHLORIDE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
|
CRAC channel 402 nM (IC 50 ) |
Orai1/Stim1 channels 25 nM (IC 50 ) |
IL-2
|
RO2959 inhibits Orai1 and Orai3 with IC
50
values of 25 nM and 530 nM, respectively. RO2959 blocks store operated calcium entry (SOCE) in activated CD4+T lymphocytes with an IC
50
value of 265 nM.
RO2959 is a potent SOCE inhibitor that blocks an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4
+
T cells triggered by either T cell receptor (TCR) stimulation or thapsigargin treatment. RO2959 completely inhibits cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-113618A | RO2959 hydrochloride | 1 mg | 1333元 | |
| 2024/08/19 | HY-113618A | RO2959 hydrochloride | 1219927-22-6 | 5mg | 3500元 |