|
|
| | PI4KIII beta inhibitor 1 Basic information |
| Product Name: | PI4KIII beta inhibitor 1 | | Synonyms: | PI4KIII beta inhibitor 1;PI4KIIIbeta-IN-10;N-[5-[3-[(4-hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide;N-(5-(3-(N-(4-HYDROXYPHENYL)SULFAMOYL)-4-METHOXYPHENYL)-4-METHYLTHIAZOL-2-YL)PIVALAMIDE;Propanamide, N-[5-[3-[[(4-hydroxyphenyl)amino]sulfonyl]-4-methoxyphenyl]-4-methyl-2-thiazolyl]-2,2-dimethyl-;PI4KIII beta inhibitor 10;inhibit,Phosphatidylinositol 4 kinases,Inhibitor,PI4 kinases,PI4K,PI4KIIIbetaIN10,PI-4KIIIbeta-IN-10,PI4KIIIbeta IN 10 | | CAS: | 1881233-39-1 | | MF: | C22H25N3O5S2 | | MW: | 475.58 | | EINECS: | | | Product Categories: | | | Mol File: | 1881233-39-1.mol |  |
| | PI4KIII beta inhibitor 1 Chemical Properties |
| density | 1.367±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 30 mg/mL (63.08 mM) | | form | Solid | | pka | 9.06±0.10(Predicted) | | color | White to off-white |
| | PI4KIII beta inhibitor 1 Usage And Synthesis |
| Biological Activity | PI4KIII beta inhibitor 1 is a potent PI4KIIIβ inhibitor with IC50 of 3.6 nM. | | in vitro | PI4KIII beta inhibitor 1 is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC 50 < /sub> ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ. | | target | | PI4KIIIβ 3.6 nM (IC 50 ) | PI4KIIIα 3 μM (IC 50 ) | PI3Kδ 720 nM (IC 50 ) | PI3KC2γ 1 μM ( IC 50 ) | PI3Kα 10 μM (IC 50 ) | PI3Kγ 20 μM (IC < sub> 50 ) | |
| | PI4KIII beta inhibitor 1 Preparation Products And Raw materials |
|