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| | Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Basic information |
| Product Name: | Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- | | Synonyms: | Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-;NCGC00244536;KDM4B INHIBITOR COMPOUND B3;CS-2874;KDM4B-IN-B3;KDM4B Inhibitor B3;NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536;3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide | | CAS: | 2003260-55-5 | | MF: | C25H22N2O2 | | MW: | 382.45 | | EINECS: | | | Product Categories: | | | Mol File: | 2003260-55-5.mol |  |
| | Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Chemical Properties |
| Boiling point | 646.9±55.0 °C(Predicted) | | density | 1?+-.0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF:30.0(Max Conc. mg/mL);78.44(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM)
DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM) | | form | A crystalline solid | | pka | 4.81±0.40(Predicted) | | color | Light yellow to green yellow |
| | Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Usage And Synthesis |
| Biological Activity | NCGC00244536 is a potent KDM4B inhibitor with IC50 of 10 nM. | | in vitro | NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC 50 =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4 . NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC 50 s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC 50 s. | | in vivo | Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis . |
| | Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Preparation Products And Raw materials |
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