| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CAY10677
CAS:1443253-20-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
|
| Tel: |
025-58851786 17714337195 |
| Email: |
sales@tybiochem.com |
| Products Intro: |
Product Name:CAY10677
CAS:1443253-20-0
Purity:95+% Package:1g;5g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CAY10677
CAS:1443253-20-0
Purity:98% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:CAY10677
CAS:1443253-20-0
Purity:详情请点击官网 Package:1 mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:CAY10677
CAS:1443253-20-0
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| | CAY10677 Basic information |
| Product Name: | CAY10677 | | Synonyms: | CAY10677;5-[3-(diethylaminomethyl)-1-octylindol-5-yl]pyrimidin-2-amine;1H-Indole-3-methanamine, 5-(2-amino-5-pyrimidinyl)-N,N-diethyl-1-octyl- | | CAS: | 1443253-20-0 | | MF: | C25H37N5 | | MW: | 407.59 | | EINECS: | | | Product Categories: | | | Mol File: | 1443253-20-0.mol |  |
| | CAY10677 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 16 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml | | form | A crystalline solid |
| | CAY10677 Usage And Synthesis |
| Description | Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Isoprenylcysteine carboxyl methyltransferase (Icmt) catalyzes the methylation of C-terminal prenylcysteine residues, the last step in this process. CAY10677 is an analog of the Icmt inhibitor cysmethynil that was developed for improved solubility and cell permeability.1 CAY10677 inhibits Icmt with an IC50 value of 0.86 μM and demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC50s = 2.63 versus 27.4 μM, respectively) and human prostate cancer PC3 cells (IC50s = 2.55 versus 25.2 μM, respectively).1 | | References | 1. Ramanujulu, P.M., Yang, T., Yap, S.Q., et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt) Eur. J. Med. Chem. 63,378-386(2013). |
| | CAY10677 Preparation Products And Raw materials |
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